Peroxisome proliferated activated receptors (PPARs): opportunities and challenges for ocular therapy
… Peroxisome proliferator-activated receptors are key players in … components of the outer
blood retinal barrier (BRB) that … dysfunction in streptozotocin-induced diabetic rats. Exper …
blood retinal barrier (BRB) that … dysfunction in streptozotocin-induced diabetic rats. Exper …
[HTML][HTML] Diabetic retinopathy: Involved cells, biomarkers, and treatments
J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
… In an experimental model of diabetes, activated microglial cells penetrated the basement …
overexpression of peroxisome proliferator-activated receptor α by mediating its methylation to …
overexpression of peroxisome proliferator-activated receptor α by mediating its methylation to …
Implications of the endogenous PPAR-gamma ligand, 15-deoxy-delta-12, 14-prostaglandin J2, in diabetic retinopathy
… orphan receptors, PPARs (peroxisome proliferator-activated … to breakdown of the inner
blood-retinal barrier, and hence … proteins in the retina of streptozotocin-induced diabetic rats …
blood-retinal barrier, and hence … proteins in the retina of streptozotocin-induced diabetic rats …
[HTML][HTML] … of peroxisome proliferator-activated receptors (PPARs) with diabetic retinopathy in human and animal models: analysis of the literature and genome browsers
Š Tajnšek, D Petrovič, M Globočnik Petrovič, T Kunej - PPAR research, 2020 - hindawi.com
… neovascularization by a peroxisome proliferator- activated receptor-γ ligand,” … the peroxisome
proliferatoractivated receptor-gamma coactivator-1 gene might be a risk factor for diabetic …
proliferatoractivated receptor-gamma coactivator-1 gene might be a risk factor for diabetic …
[HTML][HTML] Rodent models of diabetic retinopathy as a useful research tool to study neurovascular cross-talk
K Polewik, M Kosek, D Jamrozik, I Matuszek… - Biology, 2023 - mdpi.com
… Whereas, Yang et al. did not find any obvious microvascular changes in db/db mice alive
for 28 weeks, suggesting that the blood retinal barrier was undamaged. He was paying …
for 28 weeks, suggesting that the blood retinal barrier was undamaged. He was paying …
The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular …
A Usui-Ouchi, Y Ouchi, N Ebihara - International Immunopharmacology, 2017 - Elsevier
… effects of the selective peroxisome proliferator-activated … inflammatory effects in an
oxygen-induced retinopathy model in … of the outer blood-retinal barrier in diabetic conditions [8]. …
oxygen-induced retinopathy model in … of the outer blood-retinal barrier in diabetic conditions [8]. …
Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection: Agmatine in diabetic retinopathy
… It is an endogenous ligand of α … its associated signaling cascades including activation of
cAMP-dependent protein kinase A and the peroxisomal proliferator-activated receptor-α and its …
cAMP-dependent protein kinase A and the peroxisomal proliferator-activated receptor-α and its …
[HTML][HTML] Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
… , peroxisome proliferator-activated receptor-γ agonizts, glucokinases agonizts, mitochondrial
energy modulators, etc. are under active development. DPDs are proposed for patients to …
energy modulators, etc. are under active development. DPDs are proposed for patients to …
[HTML][HTML] Evaluation of the possibility of selective modulation of retinal glucose transporters in diabetic complications: An experimental study
… However, in terms of blood retinal barrier, GLUT1 is exclusively … ligand screen assay was
done to analyze the affinity of genistein for peroxisome proliferator-activated receptor gamma …
done to analyze the affinity of genistein for peroxisome proliferator-activated receptor gamma …
[HTML][HTML] Endothelial dysfunction in diabetic retinopathy
F Gui, Z You, S Fu, H Wu, Y Zhang - Frontiers in Endocrinology, 2020 - frontiersin.org
… result in the breakdown of the blood–retinal barrier (BRB) and … networks mediated by
proliferator-activated receptor-γ (… the antioxidant effects of the PPARγ ligand on oxidative stress in …
proliferator-activated receptor-γ (… the antioxidant effects of the PPARγ ligand on oxidative stress in …